Kato et al. [33] found the expression of MAdCAM-1 significantly increased with a prolonged time in DSS-induced colitis in mice, and there were a large number of integrin and lymphocyte gathering into the colitis site, suggesting that MAdCAM-1 was the main inducible factor which mediates lymphocyte migration to the inflammatory colonic mucosa. Here, MADCAM1 is linked to colitis.