Furthermore, restored miR-491-3p expression was reported to suppress the invasion of osteosarcoma cells by directly targeting αB-crystallin (CRYAB) [24, 28] and the metastasis of hepatocellular carcinoma by blocking epithelial-mesenchymal transition and decreasing matrix metalloproteinase-9 levels [29]. This evidence concerns the gene CRYAB and hepatocellular carcinoma.