Our study is the first to show a strong association between t-PA level and the need for coronary interventions by univariate analysis, where patients who underwent CABG or PCI had higher t-PA levels than those who had no interventions, suggesting that t-PA levels can also assess the severity of atherosclerosis disease and predict the need for coronary intervention by PCI or CABG. Here, PLAT is linked to atherosclerosis.