The molecular consequences of the Ph chromosome form the BCR-ABL oncogene that encodes a chimeric BCR-ABL oncoprotein, which disrupts several factors (leptin, IL-8, MMP-9, and survivin) and pathways (Ikaros/Notch/CD-11d signaling pathways) responsible for the pathogenesis of leukemia. The gene discussed is ABL1; the disease is leukemia.