In the present systematic review and meta-analysis, we found that 6 subtypes of malignant salivary gland tumors had positive HER2 rates higher than 20%, including salivary duct carcinoma in situ, SDC, CXPA, poorly differentiated adenocarcinoma, adenocarcinomas not otherwise specified (NOS), squamous cell carcinomas and mucoepidermoid carcinomas. The gene discussed is ERBB2; the disease is squamous cell carcinoma.