As shown in Figure 3 and Table 2, the baseline serum S100B, IL-1β, and IL-2 levels of GAD cases were significantly lower than HC (P < 0.001), the IL-4 levels were higher than HC (P < 0.001), and there was no significant difference in IL-10 between the two groups (P = 0.215). This evidence concerns the gene IL1B and generalized anxiety disorder.