The current study investigated the effect of CdCl2 on infertility in male rats and potential effects of lycopene, CoQ10, LC, ZnSO4, and LC-CoQ10 on CdCl2-induced infertility through assessing semen parameters, measuring testosterone and testicular antioxidants level such as SOD, CAT, and GSH, as well as evaluating testicular histology. The gene discussed is SOD1; the disease is Infertility.