• Neutralizing antibodies against SARS-CoV-2 were lower in CLD 77.3% vs 90.3% in healthy (P = 0.001). • Non-cirrhotic CLD 76.8% • Compensated cirrhosis 78.9% • Decompensated cirrhosis 76.7% • Grade 3 ALT elevation in 3 patients and 1 patient related to vaccine and develop liver failure • Male sex is an independent factor of lower immune response. The gene discussed is GPT; the disease is congenital secretory chloride diarrhea 1.