From eight identified genes whose expression in endothelial and stellate cells (liver-resident fibroblasts activated in CLD to support the tumor-promoting microenvironment) correlated with survival in HCC patients (54), four were potential oncogenes with high expression in HCC (CKS2, HSP90AB1, RPL12, S100A6) and two were potential tumor-suppressor genes (CCL14 and CD5L) with low expression. This evidence concerns the gene HSP90AB1 and hepatocellular carcinoma.