Aberrant expression of FGFR4 has been reported to contribute to HCC progression (87), and proteins in the corresponding network were enriched for the MAPK cascade, which plays a pivotal role in HCC development due to activation by upstream growth factors (88), whereas APOA1 is prognostic for survival in HCC patients and predictive of early recurrence. The gene discussed is FGFR4; the disease is hepatocellular carcinoma.