Further implicated in the emergence of HCC are transcriptional dysregulation of genes involved in the WNT/b-catenin pathway and enrichment of the humoral response pathway, whereas pathways implicated in recurrent HCC include IL-6 growth signaling, NF-kB, IFN-gamma and HNF4a pathways. This evidence concerns the gene NFKB1 and hepatocellular carcinoma.