Their induced deficiency of the G protein-coupled receptor (Gpr)126 (encoded by the ADGRG6 gene and previously linked to AIS) resulted in 1) a loss of cartilage quality, manifesting as AIS and PE and 2) the up-regulation of Gal3st4, a protein likewise linked to PE [57]. The gene discussed is ADGRG6; the disease is androgen insensitivity syndrome.