ECM1 can bind to integrins on the cell surface and then bind to the N-terminal domain of focal adhesion kinase (FAK) to activate FAK, which can inhibit tumor cell apoptosis by mediating the Akt pathway, promote tumor cell surface adhesion, and activate phosphatidylinositol-3-kinase (PI3K) (102–104). This evidence concerns the gene PTK2 and neoplasm.