Representative results for the key regulators of oxidative stress and metabolism are shown in Figure 7B, including TXNRD1 (encoding the Thioredoxin reductase TrxR1), the reductase-encoding genes SRXN1 (encoding SRX1), HTATIP2 (encoding HIV1 TAT-Interactive Protein 2), AKR1b10 (encoding a member of the aldo/keto reductase superfamily), and TKT (encoding transketolase), as well as NFE2L2 (encoding the master antioxidant transcription factor NRF2) that governs the antioxidant stress in various cancers through the Keap1-NRF2-p62 pathway. The gene discussed is KEAP1; the disease is cancer.