KEAP1 and neoplasm: In agreement with its tumor-promoting role in LIHC, the p62 level in LIHC has a remarkable association with p53-mediated cell cycle regulation and cell survival/proliferation, WNT/β-Catenin-mediated cell proliferation, and Keap1-NRF2 antioxidative stress (Figure 9C and Supplementary Figure 2).