The tumor-promoting properties of p62 are underscored by the facts that p62 is upregulated in different cancer contexts, including LIHC, and breast and prostate cancers (2, 13–17), and that p62 is induced by the oncoprotein Ras that accounts for more than 25% of human cancers (18). This evidence concerns the gene SQSTM1 and Familial prostate cancer.