To explore the relationship between nrlncRNA signatures and immune cell infiltration, we used XCELL, TIMER, QUANTISEQ, EPIC MCPCOUNTER, CIBERSORT, and CIBERSORT-ABS algorithms to compare the content of immune cells in different risk score groups and found that the high-risk group was positively correlated with tumor-infiltrating immune cells such as cancer-associated fibroblast, T cell CD8+, M2 macrophages, and macrophages. The gene discussed is CD8A; the disease is cancer.