In addition, among the 22 immune cells analyzed by CIBERSORT (Figure 5G and Supplementary Figures S9G, S10G), CD8+ T cell infiltration was decreased, while M2 macrophages were increased across the three datasets (Figures 5E, F and Supplementary Figures S9E, F, S10E, F), further demonstrating the potential role of LGALS genes in glioma immunosuppression and immune escape. Here, CD8A is linked to central nervous system cancer.