Data acquired from The Cancer Genome Atlas (TCGA) revealed that high DNA methylation of the FBXW7 was accompanied with high KDM5c (a histone demethylase) expression, which might ascribe to the recruitment of DNMT3b induced by interaction of KDM5c and H3K4me3 of FBXW7 downstream so that the CpG of FBXW7 could be methylated, followed with inhibited FBXW7 expression (47a). Here, FBXW7 is linked to cancer.