IFN-γ stimulating the IFNGR1 receptor complex induces the transcription factors including Signal Transducer and Activator of Transcription 1 (STAT1) and Interferon Regulatory Factor 1 (IRF1) to actuate the type II IFN response genes and chronic inflammatory reaction in prostate carcinoma cells (48). The gene discussed is IRF1; the disease is prostate carcinoma.