FBXW7 and B-cell chronic lymphocytic leukemia: On regulation of lymphocytes, FBXW7 deficiency of progenitors in bone marrow lose the ability to colonize the thymus, resulting in a significant shortage of T lymphocyte progenitors and an obvious decline of all B lymphocytes, and FBXW7 is considered as a driver gene for CLL ascribe to its mutations and degradation of NOTCH1 (155, 156).