A research to detect the DNA methylation, histone methylation, histone acetylation, and chromatin remodeling uncovered that H3K27 acetylation suppressed by the mutation or knockdown in CREBBP or EP300 in B-lymphoma cells weakened the expression of FBXW7, leading to the activation of NOTCH pathway and thereby caused the tumor-associated macrophage (TAM) polarizing to M2 phenotype and proliferation of tumor cells (46). The gene discussed is EP300; the disease is neoplasm.