In the current study, we assessed the impact of clinical characteristics, CMB and WML, and cognition-related genes (COMT, BDNF, KIBRA, APOE, and KLOTHO) on neurocognitive outcomes in a cohort of pediatric cancer survivors, enriched with CNS tumors, using an established multi-institutional cohort (Rad ART Pro) (29, 33). This evidence concerns the gene BDNF and central nervous system neoplasm.