CXCR4 and familial pancreatic carcinoma: In various cancers such as breast cancer, high grade serous ovarian cancer, and murine ovarian and pancreatic cancer models (91), a subset of TAFs were shown to associate with the recruitment and differentiation of Tregs in the TME, again via the secretion of SDF-1 (CXCL12) and its interaction with its receptor CXCR4.