IL1 is responsible for the induction and autocrine production of IL6 in RCC cells (45–47); moreover, IL1 can target distinct RCC cell lines in vitro to induce NF-kB activation, metalloprotease (MMP) production, and cell adhesion molecule (e.g., ICAM1) expression favoring proliferation and invasiveness (48–50). This evidence concerns the gene NFKB1 and renal cell carcinoma.