VHL and nonpapillary renal cell carcinoma: Next, we analyzed the TLR pathway in different cell lines representative of different kidney tumor types: A498 (clear cell RCC, VHL mutated), CAKI1 [clear cell RCC, metastatic, VHL wt), CAKI2 (initially defined as ccRCC VHL wt, but recent data suggest that it is a primary papillary RCC cell line (41)], and ACHN (papillary RCC, metastatic, VHL wt).