Lower levels of SIGIRR and of TOLLIP, NFRKB, TNFRSF1A, and CD14 and of two distinct MAP kinases were detected in all the cancer cell lines analyzed (Figure 1B); on the contrary, IRAK1 and HSPD1 mRNAs were upregulated in all the tumor cells (Figure 1C). This evidence concerns the gene SIGIRR and cancer.