PFKFB3 and colorectal carcinoma: Another miRNA involved in CRC was reported by Xiao et al. They found that the exosomal delivery of miR-1915-3p can improve the chemotherapeutic efficacy of oxaliplatin in CRC cells by suppressing the expression of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) and ubiquitin carboxyl-terminal hydrolase 2 (USP2) and inducing the expression of E-cadherin (148).