In fact, the exposition to MSC-EVs induced in gastric cancer cells HGC-27, MGC-803, and SGC-7901 the activation of calcium/calmodulin-dependent protein kinases (CaM-Ks) and Raf/MEK/ERK kinase pathways, culminating in the upregulation of MDR, multidrug resistance-associated protein (MRP) and lung resistance-related protein (LRP), and finally, insensitiveness to apoptosis induced by 5-FU. This evidence concerns the gene MVP and gastric cancer.