Many papers reported the mechanisms of resisting cell death induced by EVs: multiple myeloma cells reduced by EVs the levels of the pro-apoptotic protein Bcl-2-like protein 11 (Bim); the antiapoptotic protein survivin is shuttled in EVs from HeLa cervical carcinoma cells irradiated with a sublethal dose of proton, and both gastric- and bladder cancer-derived EVs suppressed the apoptosis of respective cancer or suppressive immune cells via the upregulation of Bcl-2 and cyclin-D1 expression and the downregulation of Bax and caspase-3 (43–48). Here, BCL2L11 is linked to urinary bladder cancer.