PTEN and hepatocellular carcinoma: In HCC, Fu and colleagues found that HCC cells Bel7402 resistant to 5-FU produce EVs enriched in miR-32-5p shuttled to sensitive parental cells, in which it induces a decrease in PTEN and the activation of the PI3K/Akt, triggering EMT, angiogenesis, and finally, chemoresistance (156).