Cancer-deduced p53 mutants are known as TP53 mutate gene. Approximately among 74% of missense mutations, 80% of them occur in the DNA-binding domain (DBD) of the p53Two types of p53 mutants are known: DNA-contact mutants and conformational mutantsMost of the p53 mutants lose track of native-type function, and some p53 mutants have been obtained GOF (gain-of-functions) that move up chemo-resistance. Here, TP53 is linked to cancer.