A significant difference between control siRNA and SMG1 siRNA control was not observed in our study, which is consistent with the fact that the activation or function of SMG1-UPF3B by phosphorylation is closely involved in GLA-accelerated decay of MDM2 and RNF6 mRNAs and the SMG1-UPF3B pathway is inactivated in gastric cancer cells in the absence of GLA. Here, UPF3B is linked to gastric cancer.