The crosstalk between the lncRNAs, NEAT1 and MALAT1, and Notch pathway has been well documented in the context of oral squamous cell carcinoma where NEAT1 upregulates proliferation and EMT and represses apoptosis through activating VEGF-A and Notch signaling pathway (46) and in the context of chondrosarcoma for MALAT1 that contributes to the proliferation of tumor cells by activating Notch-1 signaling pathway (47). Here, VEGFA is linked to chondrosarcoma.