Our data showed an example of the complex interplay between miR-378a-3p and the lncRNAs MALAT1 and NEAT1 and thus the disruption of this ncRNA regulatory network can alter the expression of genes involved in the EMT process (TGFB1, TGFB2, SNAI1, beta-catenin, AKT and JAG-1) in CRC. This evidence concerns the gene MALAT1 and colorectal carcinoma.