As first validation of this potential interaction, we observed by qRT-PCR analysis that ectopic expression of miR-378a-3p significantly downmodulated MALAT1 expression in both CRC cells (HT29, DLD1 and HCT116) and CRC-SC lines (CRC-SC#18 and CRC-SC#85) transduced with TRIPZ-miR-378 compared to TRIPZ transduced cells (Figures 4A, B). Here, MALAT1 is linked to colorectal carcinoma.