Particularly, JAG-1, involved in Notch signaling pathway, and AKT1, a critical player in tumorigenesis, were downmodulated in all the CRC cells and CRC-SC lines analyzed, even though, as luciferase reporter assay proved, neither JAG-1 nor AKT1 are miR-378a-3p direct targets, at least in the CRC cell line used for these analyses. Here, AKT1 is linked to colorectal carcinoma.