High expression of CBX8 in HCC enhances proliferation and migration by activating the AKT/β-catenin signaling pathway (26), while in glioblastoma cells, breast cancer cells and lung cancer cells, CBX8 can strengthen proliferation and invasion capacity by activating the WNK2/MMP2 signaling pathway, ultimately leading to metastasis (12). This evidence concerns the gene MMP2 and hepatocellular carcinoma.