(27) also confirmed that the expression of CBX8 was inversely proportional to the survival rate of patients with bladder cancer and was highly expressed in patients with stage III and IV advanced tumors and lymph node metastasis, which was consistent with the results obtained in our analysis of CBX8 and clinicopathological features.These results suggested that high expression of CBX8 leads to poor prognosis in LSCC patients. The gene discussed is CBX8; the disease is urinary bladder cancer.