Furthermore, IHC revealed that CBX8 is mainly expressed in the tumor nucleus and cytoplasm, and its expression in LSCC (Figures 1D, E) was significantly higher than that in paracancer tissues (Figure 1F), positive rate in cancer tissues and paracancer tissues were respectively 67.5%(27/40)and 22.5% (9/40)(Table 1). Here, CBX8 is linked to cancer.