TP53INP1 and pancreatic ductal adenocarcinoma: Furthermore, Mikamori et al. evidenced that long exposure to gemcitabine increased miR-155-loaded EVs secretion in pancreatic ductal adenocarcinoma, thus conferring drug resistance through inhibition of pro-apoptotic stress-induced p53 target gene tumor protein p53-inducible nuclear protein 1 (TP53INP1) (103).