Furthermore, Li and colleagues observed that miR-23a-enriched exosomes activate NF-κB pathway in macrophages by targeting its negative regulator A20 (130) while Chen and collaborators founded that exosomal miR-300 controls melanoma cell progression targeting GADD45B expression, a NF-κB-induced pro-survival factor (131). Here, NFKB1 is linked to melanoma.