Moreover, miR-155-5p in melanoma-derived exosomes triggers the proangiogenic switch of CAFs by targeting suppressor of cytokine signaling 1 (SOCS1), thus activating the janus kinase (JAK)2/signal transducer and activator of transcription (STAT)3 (JAK2/STAT3) pathway (88). This evidence concerns the gene STAT3 and melanoma.