In particular, UGT2B15 contributes to PCa risk, diagnosis and disease progression (41, 42), and 3α-diol-17 glucuronide, a product of UGT2B15/B17, is linked to prostate volume changes, indicating that this metabolite might serve as a biomarker of androgen activity. This evidence concerns the gene UGT2B15 and posterior cortical atrophy.