By employing a cell-model and 3D ex vivo organotypic culture model, Singh and colleagues showed that a high level of the detoxifying enzyme Sulfotransferase Family 1A Member 1 (SULT1A1) confers resistance to Tamoxifen and collateral sensitivity to the anticancer compounds with SULT1A1-dependent activity RITA (Reactivation of p53 and Induction of Tumor Cell Apoptosis), aminoflavone (AF), and oncrasin-1 (ONC-1) (181). Here, SULT1A1 is linked to neoplasm.