ALDH1A1 and breast carcinoma: hypothesized that ALDH1A1 was activated in the MDA-MB-468 breast cancer cell line, which stably expressed CYP2J2 and attenuated caspase-3/7 activity and the production of reactive oxygen species induced by cytotoxic agents, such as paclitaxel, doxorubicin, sorafenib, and staurosporin (52).