The bioinformatics techniques, luciferase assays, qRT-PCR, and immunoblotting revealed the supervisory pathway between the miR-30c-2-3p and ATF3. Lysophosphatidic acids can stimulate ATF3 and miR-30c-2-3p expression, as the highest expression rate occurs after one hour and disappears after 8 hours in ovarian cancer cells. The gene discussed is ATF3; the disease is ovarian cancer.