In the meantime, geniposide, an iridoid glucoside, purified from Gardenia jasminoides Ellis, was reported able to suppress the receptor for advanced glycation end product (RAGE)-related signaling such as ERK and NF-κB (63) and production of tumor necrosis factor-α (TNF-α) cerebral Aβ accumulation in an mPrP-APPswe/PS1dE9 AD transgenic mouse model at 25 mg/kg/day for 3 months (63). Here, TNF is linked to Alzheimer disease.