Additionally, we confirmed that IDH3α is not expressed and that PEPCK-M is highly expressed in the tumor stroma of human NSCLC, and further studies will determine whether loss of IDH3α and/or high PEPCK-M may be used as glycolytic markers of CAFs and whether they could have any predictive value in ADT cancers. Here, IDH3A is linked to non-small cell lung carcinoma.