In another approach utilizing the active targeted delivery of nano-drugs, integrin receptor-targeted lipid protamine-siRNA (LPR) nanoparticles were developed and used to load siRNA targeting the PAX3-FOXO1 (P3F) breakpoint, which was a specific fusion transcript of alveolar rhabdomyosarcoma (ARMS) (56). The gene discussed is FOXO1; the disease is alveolar rhabdomyosarcoma.