Furthermore, TUNEL staining showed that the proportion of cardiomyocyte apoptosis in α1A–/– mice was increased (Figures 3(h) and 3(i)), while the expression of the cleaved caspase-3 protein was significantly increased after myocardial infarction, similar to that in WT mice (Figure 3(j)). The gene discussed is CASP3; the disease is myocardial infarction.