Most genes had significant expression differences, including DNMT1, DNMT3A, DNMT3B, TET1, TET2, TET3, MBD1, MBD4, ZBTB33, UHRF1, UHRF2, UNG, TDG, NTHL1, and SMUG1, which were significantly overexpressed in tumor tissues, while ZBTB4 was significantly downregulated in tumor tissues. The gene discussed is SMUG1; the disease is neoplasm.