PTEN and pulmonary fibrosis: In addition, Kimura et al. found that exogenous administration of mutant PTEN at the C-terminus (S380A, T382A, T383A, and S385A) could restore the enzymatic activation of PTEN insulted by TGF-β1 resulting in inhibition of ECM overproduction in epithelial cells and fibroblasts in lung fibrosis [118].