Resveratrol inhibits the activation of TGF-β1-induced normal fibroblasts and IPF-derived fibroblasts, and the mechanism is probably related to upregulation of PTEN, which inhibits the phosphorylation of Akt and extracellular signal-regulated kinases (ERK1/2) [137]. This evidence concerns the gene AKT1 and idiopathic pulmonary fibrosis.