In the BLM-induced model of pulmonary fibrosis, myeloid PTEN-deficient mice exhibited enhanced TGF-β1 activation and collagen deposition, decreased number of macrophages and T cells, and aberrant macrophage polarization with augmentation of various proinflammatory cytokines such as IL-6 and TNF-α. Here, PTEN is linked to pulmonary fibrosis.