PTEN and asthma: In line with the abovementioned findings, Ni et al. reported that glucocorticoid dexamethasone treatment could transcriptionally upregulate the PTEN expression through inhibition of histone acetylation in asthmatic mice [31], suggesting that targeting PPAR-γ and histone deacetylase to restore the expression and function of PTEN is a promising strategy in the treatment of asthma.