Another study reveals that FoxO3a expression at mRNA and protein levels is significantly suppressed, which caused low autophagic activity through transcriptional suppression of LC3B in IPF-derived fibroblasts cultured on a collagen-rich matrix, thereby promoting IPF progression [110] indicating that upregulation of FoxO3a and Fas to restore phosphatase activity of PTEN might effectively prevent IPF. This evidence concerns the gene FOXO3 and idiopathic pulmonary fibrosis.