To understand whether NEK7/NLRP3 is associated with diabetic foot, Cai et al. [107] compared the expression of NEK7/NLRP3 between patients with and without diabetic foot to show that the NEK7/NLRP3 pathway, which was significantly increased in patients with diabetic foot, drove the pathogenesis of diabetic foot. The gene discussed is NLRP3; the disease is diabetic foot.