Meanwhile, the expression of CMTM4 was decreased, and p-Akt and p-ERK protein expressions were increased in tumor tissues of mice that received Exo-miR-224-5p agomir compared with the Exo-NC group, whereas mice that treated with Exo-miR-224-5p antagomir displayed the opposite results (Figures 8(g)–8(j)). This evidence concerns the gene CMTM4 and neoplasm.