ACSL4 and intervertebral disk degenerative disorder: We found elevations in expression of circ_0072464, NRF2, and GPX4 and reductions in expression of miR-431 and ACSL4 in NP tissues of IDD mice injected with EVs, while GPX4 expression reduced and ACSL4 expression elevated in NP tissues of IDD mice injected with Erastin.