We found elevations in expression of circ_0072464, NRF2, and GPX4 and reductions in expression of miR-431 and ACSL4 in NP tissues of IDD mice injected with EVs, while GPX4 expression reduced and ACSL4 expression elevated in NP tissues of IDD mice injected with Erastin. The gene discussed is GPX4; the disease is intervertebral disk degenerative disorder.