Wisp1 is expressed in several tissues, including the epithelium, heart, kidney, lung, pancreas, placenta, ovaries, small intestine, spleen, and brain (Maiese et al., 2012), and it plays an important role in diverse pathophysiological processes, such as embryonic development, inflammation, injury repair, and cancers (Feng and Jia, 2016). The gene discussed is CCN4; the disease is cancer.