The focus on xanthine oxidase inhibitors has increased due to their anti-inflammatory, antioxidant, and immune-modulatory effects, which might be beneficial in the treatment of different inflammatory diseases such as chronic obstructive pulmonary disease (COPD) and ulcerative colitis (El-Mahdy et al., 2020) and thus, it may be beneficial in alleviating oxidative stress and inflammation associated with DOX-induced cardiotoxicity. The gene discussed is XDH; the disease is chronic obstructive pulmonary disease.