The SNPs of TNF-a (rs1799724 (Murdaca et al., 2017)), IL-6 (rs1800795 (Białecka et al., 2015)), IL-17 (rs10484879 (Murdaca et al., 2017), rs4819554 (Villalpando-Vargas et al., 2021)) IL-23 (rs11209032 (Karaderi et al., 2009), rs11209026 (Teng et al., 2015), rs2201841 (Zhu et al., 2012)), IL-12B (rs6887695 (Eiris et al., 2012), rs3212227 (Cargill et al., 2007)) and other pro-inflammatory cytokines are significantly associated with the pathogenesis of psoriasis. The gene discussed is IL12B; the disease is psoriasis.