Ang II infusion is a widely used approach to induce HF in animal models (Tsukamoto et al., 2013; Cambier et al., 2018; Aghajanian et al., 2019; Wang et al., 2020) by increasing blood pressure and L-NAME, a nitric oxide synthase antagonist (Liu et al., 2019), and salt further contributes to HF. The gene discussed is AGT; the disease is hydrops fetalis.