As mentioned earlier, Nrf2 improved PD by regulating anti-inflammatory and antioxidant related proteins, such as Nrf2/HO-1, Nrf2/NF-κB, Nrf2/HO-1/NLRP3, Keap1/Nrf2, and Nrf2/HO-1/p38 (Han et al., 2022). This evidence concerns the gene HMOX1 and Parkinson disease.