L-GSH supplementation in T2DM has also been shown to increase the levels of Th1-response associated cytokines, such as IFN-γ, TNF-α, and IL-2, while diminishing the levels of immunosuppressive cytokines, such as IL-10 and IL-6 (To et al., 2021). This evidence concerns the gene IFNG and type 2 diabetes mellitus.