As shown in Figures 3C,D, compared with the rats in the C group, both PSD length and width in the striatum region of rats in the M group (p < 0.01, p < 0.01) and CC group (p < 0.01, p < 0.01) were significantly reduced, whereas treatment with XYS (p < 0.01, p < 0.01) or A2AR antagonist (p < 0.01, p < 0.01) effectively reversed the changes caused by CRS. The gene discussed is ADORA2A; the disease is congenital rubella syndrome.