Some studies have shown that astaxanthin (or astaxanthin-derived diesters) could reduce Aβ42 deposition and Tau phosphorylation, resulting in the suppression of neuroinflammation and enhancement of learning and memory in APP/SP1 transgenic mice, APPNL−G-F mice, or Aβ-infused AD rat (Che et al., 2018; Rahman et al., 2019; Taksima et al., 2019; Hongo et al., 2020). Here, MAPT is linked to Alzheimer disease.