Immune alterations in chronic tinnitus have not yet been studied extensively, but some previous findings include increased inflammatory parameters such as neutrophil-to-lymphocyte ratio (NLR; Ozbay et al., 2015; Yildiz et al., 2020; Demir, 2021) and positive associations between tinnitus-related distress and TNF-α (Szczepek et al., 2014). This evidence concerns the gene TNF and Tinnitus.