CD8A and neoplasm: Upon capturing TAA’s, DCs get activated, express CCR7, mature, and 1) migrate to draining lymph nodes, 2) present the captured antigens to naïve CD4+ and CD8+ T-cells via the major histocompatibility complex (MHC) class I and II molecules, 3) express T-cell costimulatory molecules, for example, CD40, CD80, and CD86, 4) secrete critical cytokines to regulate T-cell responses, 5) activate naïve CD8+ T-cells converting them into cytotoxic T-cells, which immigrate from lymphoid organs into the bloodstream and reach tissues and ultimately infiltrate the tumor.