After the safety confirmation of the transient CAR mesothelin expression, a second phase I clinical trial (NCT02159716) was conducted on 15 patients with mesothelioma, ovarian, and pancreatic cancer; the used CARs were expressing the same second-generation murine-based anti-mesothelin constructed using a lentiviral transduction vector (Haas et al., 2019). The gene discussed is MSLN; the disease is familial pancreatic carcinoma.