Thus, clinicians must pay attention to this condition to prevent fatal outcomes HLH/MAS post CAR T-cell therapy in association with CAR T-cell induced toxicities (CARTOX) score, which includes serum ferritin levels >10.000 ng/ml and one of the following: oliguria grade ≥3 or elevated serum creatinine grade ≥3, pulmonary edema, elevation in serum bilirubin, aspartate aminotransferase or alanine aminotransferase grade ≥3, and incidence of hemophagocytosis bone marrow (Mei et al., 2018). The gene discussed is GPT; the disease is Hemophagocytosis.