Also, tumor cell apoptosis can be initiated via the activation of caspase 8 and the formation of death-inducing signaling complex (DISC) leading to cell death mediated by mature caspase 3 subsequent cleavage of over 500 cellular substrate as a result of Fas and Fas ligand (FasL) pathway activation (Waring and Müllbacher, 1999; Nagata and Tanaka, 2017) (Figure 3). This evidence concerns the gene FASLG and neoplasm.