MAPT and Alzheimer disease: To further investigate the effects of Aβ and tau photo-oxygenation in vivo, photo-oxygenation using photocatalyst 4 was performed in a living AD model mouse, AppNLGF/NLGF, which is a knock-in mouse of human Aβ harboring familial AD mutations, demonstrating the age-dependent deposition of Aβ in the brain (Saito et al., 2014).