Two pathways that are not as targeted by AD indications yet score highly in our literature-based ranking are apoptosis and the proteasome. Additionally, only 2 of the 206 drug-assigned gene targets are also GWAS hits:, namely, atorvastatin that targets HMGCR (Moreno-Grau et al., 2019) and avagacestat that targets APH1B (Jansen et al., 2019), both of which were investigated to delay the onset of AD (Supplementary Table 10). The gene discussed is APH1B; the disease is Alzheimer disease.