A total of 99 genes were extracted that exhibited directional coherence for interaction between HFD and Plcg2M28L in mice and change in expression in AMP-AD modules in Consensus Cluster A, such as Aldh2, Aldh6a1, Aldh7a1, lamb2, Rab31, and Sox9 (Supplementary File 3). The gene discussed is ALDH6A1; the disease is Alzheimer disease.