In addition, B6 mice do not develop overt type 2 diabetes when fed with an HFD, but they are a model for early stages of the disease with phenotypes that include obesity, mildly elevated non-fasting blood glucose, increased serum glucose, glucose intolerance with advancing age and elevated triglycerides, glucose, HDL, LDL, insulin, and leptin (Collins et al., 2004)6. Here, INS is linked to Glucose intolerance.