CLDN5 and Alzheimer disease: We identified a total of 192 genes that exhibit a directional coherence between interaction with HFD and Plcg2M28L in mice and a change in the expression in immune-associated AMP-AD modules in Consensus Cluster B, including microglia-related genes, such as Trem2, Tyrobp, Cldn5, and C1qc (Figure 5E and Supplementary File S3).